Pharmacognosy · Phytomedicine

Ginger

Zingiber officinale Roscoe — One of the most versatile medicinal rhizomes in the world, with 101 references spanning antiemetic, anti-inflammatory, antidiabetic, antiviral, and analgesic pharmacology across gingerols, shogaols, and zingiberene.

101Primary Refs
25+Properties
RhizomeParts Used
✦Researched
Last Updated
Primary SourceWikiphyto · NCBI PubMed
FamilyZingiberaceae

Biological Overview

Ginger is one of the world's most studied medicinal rhizomes, used continuously across Asian, Middle Eastern, and European medical traditions for millennia. Its complex phytochemical matrix — gingerols, shogaols, paradols, and zingiberene — accounts for a broad and well-evidenced pharmacological profile spanning antiemetic, anti-inflammatory, antidiabetic, antiviral, cardiotonic, and analgesic domains. Listed in the French Pharmacopoeia and assessed by the EMA.

Key ActivesGingerols, Shogaols, Zingiberene
Primary TargetsCOX/LOX, 5-HT3/D2, TRPV1, NF-κB
EO Content1–4% v/m (rhizome)
Starch Content50–60% (dried rhizome)
Botanical Classification

Taxonomy & Identification

Latin Name
Zingiber officinale Roscoe
Family
Zingiberaceae
Common Names
Ginger, Gingembre, Jengibre
Sanskrit Name
Shringavera ("antler-shaped")
Parts Used
Rhizome, Essential oil
Origin
South-East Asia (India, West)
Cultivation
All tropical zones worldwide
Morphology & Distribution

Description & Habitat

Ginger is a large perennial tropical herb with a reed-like bearing, growing from a branched, fleshy rhizome that forms the basis of all medicinal and culinary use. Its aerial stems bear linear-lanceolate leaves and a dense spike inflorescence with white or yellow flowers surrounded by bracts. The rhizome — commonly called the "root" — is hand-shaped, knobbly, and intensely aromatic.

Native to tropical South and South-East Asia, ginger is now cultivated throughout all tropical zones — India, Jamaica, China, West Africa, the Caribbean, Australia, and beyond. India remains the world's largest producer. The plant's rhizome "eyes" give rise to new buds seasonally, allowing vegetative propagation across tropical climates.

Etymology

The botanical name Zingiber derives from the Sanskrit shringavera, meaning "antler-shaped" — a reference to the form of young shoots emerging from the rhizome. The name passed through Greek zingiberis and Latin zingiber into most European languages.

Morphological Profile
HabitLarge perennial tropical herb, reed-like
LeavesLinear-lanceolate, alternate, sheathing
InflorescenceDense spike, white or yellow flowers, bracts
RhizomeBranched, hand-shaped, aromatic, fleshy
PropagationVia rhizome buds ("eyes")
EO yield1–4% from dried rhizome

Quality & Standardisation Note

Ginger dietary supplements require quality control and standardisation including quantitative analysis of gingerols and shogaols, as concentrations vary substantially by geographic origin, processing method, and storage conditions — variables that directly affect clinical efficacy. [4]

Ethnobotany & Traditional Use

History & Tradition

Ginger has been prized since remote antiquity — the Wikiphyto source notes it was so valued in the Middle Ages that it was believed to come from the Garden of Eden. Cultivated as a spice and condiment across all tropical countries, it forms part of traditional medicine in India, China, the Arab world, and the Caribbean, and entered European pharmacy via ancient trade routes.

Ancient India & China

Ayurveda & Traditional Chinese Medicine

Ginger — called shringavera in Sanskrit — was a foundational herb in Ayurvedic practice for digestive, respiratory, and rheumatic conditions. In Traditional Chinese Medicine it was prescribed for cold-induced vomiting, cough, and yang-deficiency conditions.

Arab & Islamic Medicine

Aphrodisiac & Digestive Tonic

In Arabic medicine, ginger was classified as a warming aphrodisiac and tonic. Ibn Sina described it for digestive weakness and sexual debility. It forms part of the classic Fioravanti's alcoolat — a compound preparation used in European pharmacy from the Renaissance onward.

Medieval Europe

The Spice of Eden

Ginger was so prized in medieval Europe it was believed to originate in the Garden of Eden. It entered European trade via Arab intermediaries and became among the most valuable spices in medieval commerce, used in cuisine, medicine, and brewing (ginger ale, ginger beer).

Modern Era

French Pharmacopoeia & EMA

The rhizome is listed in the French Pharmacopoeia Liste A. The EMA/HMPC published a revised herbal monograph (EMA/HMPC/885789/2022) in May 2025 establishing well-established and traditional use categories for antiemetic and digestive indications.

Medieval Tradition

"Ginger was so prized in the Middle Ages it was thought to come from the Garden of Eden — a testament to its extraordinary therapeutic reputation across cultures and centuries."

Wikiphyto — Histoire et tradition

Ginger also enters the composition of Soshiho-tang, a classical traditional Chinese and Japanese multi-herb preparation, and ginger-ale — a beverage that preserves the plant's digestive and carminative reputation in popular culture globally.

Therapeutic Material

Parts Used & Available Formulations

The rhizome is the primary medicinal part in all forms; the essential oil distilled from it is used separately in aromatherapy and topical applications.

Dried Rhizome Powder

The most clinically studied form. Standardised powdered rhizome in capsules at 500–2000 mg/day is used in RCTs for nausea, dysmenorrhoea, diabetes, and migraine. Gingerol and shogaol content must be verified for standardisation.

Mother Tincture & Infusion

Hydroalcoholic tincture of the underground part for oral use. Fresh ginger infusion (sliced rhizome in hot water) retains heat-labile constituents including fresh gingerols and is used for travel sickness, nausea of pregnancy, and digestive complaints.

Essential Oil

Steam-distilled from fresh or dried rhizome. Rich in zingiberene (30%) and β-sesquiphellandrene (10%). Used by inhalation for postoperative nausea, topically for arthritic and muscular pain, and as an immunostimulant. Requires dilution — dermocaustic at pure concentration.

Clinical Dosing

Usual Dosages

Based on EMA/HMPC herbal monograph on Zingiber officinale rhizome (Revision 1, EMA/HMPC/885789/2022, May 2025) and clinical trial data. [2]

Indication Formulation Dose Timing
Motion sickness — adultsRhizome powder750–2000 mg30–60 min before travel
Motion sickness — children 6–12 yrsRhizome powder250–500 mg30–60 min before travel
GI complaints (adults)Rhizome powder180–1000 mg3× daily
Type 2 diabetes (clinical trials)Dried rhizome powder1000–2000 mg/daySplit doses with meals
DysmenorrhoeaRhizome powder500 mg 3× daily or 250 mg 3× daily3–5 days from onset of menstruation
Nausea of pregnancy / chemotherapyRhizome powder1000–2000 mg/dayDivided doses throughout day
Biochemical Profile

Composition

The rhizome contains a distinctive matrix of arylalkane pungent principles (gingerols, shogaols), sesquiterpene-rich essential oil, diarylheptanoids, and abundant starch — each fraction contributing distinct pharmacological activities.

Rhizome — Pungent Principles

GingerolsPrimary pungent arylalkane compounds (6-, 8-, 10-gingerol); anti-nausea, anti-inflammatory, cardiotonic, TRPV1 activators
Key
ShogaolsDehydration products of gingerols; more potent than gingerols in several bioassays; formed on drying; antiemetic, anticancer
Potent
ParadolsReduction products of shogaols; antioxidant and antimutagenic activity; free radical scavenging among the most potent known
Antioxidant
DiarylheptanoidsGingerediones A and B; galanolactone (Chinese variety); anti-inflammatory and serotonin antagonist activity
Anti-5HT3
Starch50–60% of dried rhizome; dietary bulk and substrate
50–60%
Lipids3–10%; includes phospholipids and triglycerides
3–10%
VitaminsVitamin A and niacin (vitamin B3)
Vitamins

Essential Oil (1–4% v/m)

Zingiberene~30%; dominant sesquiterpene hydrocarbon; anti-inflammatory, carminative; chemotaxonomic marker
~30%
β-Sesquiphellandrene~10%; antiviral (rhinovirus), antibacterial, antifungal; bioavailability enhancer
~10%
β-Bisabolene3–6%; anti-inflammatory sesquiterpene
3–6%
α-Farnesene4–5%; sesquiterpene; antiviral and anti-inflammatory
4–5%
ar-Curcumene2–5%; sesquiterpene shared with turmeric; anti-inflammatory
2–5%
MonoterpenesCamphene, geranial, neral, linalool, citronellal; digestive, antispasmodic, aromatic
Minor
Other acidsGingersulfonic acid, pipecolic acid, cinnamic acid, glycerols
Accessory

6-Gingerol — Key Active

TRPV1 Channel Activator

Both gingerols and shogaols are activators of the TRPV1 (transient receptor potential vanilloid 1) channel — the same receptor targeted by capsaicin — producing counter-irritant analgesia and contributing to ginger's antipruritic and analgesic effects. [24]

Cardiotonic (Ca²⁺-ATPase)

[8]-gingerol activates the Ca²⁺-pumping ATPase of sarcoplasmic reticulum in guinea pig atrial muscle — a cardiotonic mechanism distinct from classical cardiac glycosides. [39]

6-Shogaol — Anticancer

6-gingerol and especially 6-shogaol inhibit growth and modulate angiogenic factor secretion in ovarian cancer cells and hepatoma (HepG2) cells — identified as key anticancer constituents. [51]

Bioavailability Enhancer

Ginger in a pharmaceutical formulation improves the bioavailability of co-administered compounds — a property attributed to β-sesquiphellandrene and other EO constituents acting on intestinal absorption mechanisms. [57]

Plant Properties — Pharmacodynamics

Rhizome biological activities with primary literature citations

25+ Properties French Pharmacopoeia EMA Assessed

Stomachic & Digestive

Ginger increases salivary flow and intestinal peristalsis, supports digestion, and has antiulcer activity. A review of 12 commonly used medicinal herbs confirms its digestive tonic properties. [5]

Antiemetic

A powerful antiemetic, superior to placebo and as effective as metoclopramide for postoperative nausea. Shogaols and gingerols act on D2 and 5-HT3 receptors. Systematic review of RCTs confirms clinical efficacy. [9][10]

Gastroprotective

Ginger oil protects against aspirin- and pylorus ligation-induced gastric ulcers in rats. In vitro activity against Helicobacter pylori has also been demonstrated, supporting its antiulcer traditional use. [11][12]

Hepatoprotective

Ethanolic extract of Zingiber officinale rhizomes demonstrates protective activity against liver cirrhosis in vivo, attributed to its antioxidant and anti-inflammatory constituents. [13]

Anti-inflammatory

Broad anti-inflammatory activity documented across multiple models — rat paw oedema, osteoarthritic cartilage explants, knee pain in OA patients. Mechanism involves Akt inhibition, NF-κB activation (releasing anti-inflammatory cytokines), and prostaglandin/leukotriene synthesis inhibition. [14][15][16][17][18][19][20]

Analgesic

Ginger reduces muscle pain caused by eccentric exercise. A systematic review of clinical trials confirms moderate analgesic efficacy. Gingerols and shogaols activate TRPV1 channels, contributing to counter-irritant analgesia. [22][23][24]

Tonic & Adaptogenic

Red ginger demonstrates tonic properties. Ginger attenuates acute and chronic restraint stress-induced perturbations in experimental animals, supporting its classification as an adaptogenic plant. [25][26]

Antioxidant

Curcumin, gingerols, shogaols, and paradols are powerful free radical scavengers. Paradols are ranked among the most potent natural antioxidants known. Ginger also protects DNA against hydrogen peroxide-induced damage. [29]

Immunostimulant

Ginger stimulates humoral and cell-mediated immune responses in experimental models. Evidence-based systematic review confirms immunomodulatory activity across multiple human and animal studies. [27][28]

Aphrodisiac & Spermatogenic

Ginger has a traditional reputation as an aphrodisiac. Studies using herbal aphrodisiacs in Arab medicine confirm increased sperm count and motility in experimental models. [30]

Antidiabetic

Clinical studies and meta-analyses confirm that powdered rhizome improves insulin sensitivity, stimulates insulin secretion, and reduces fasting blood glucose and HbA1c in type 2 diabetic patients across multiple RCTs. [31][32][33][34][35][36]

Hypolipidaemic & Antithrombotic

Ginger demonstrates antidiabetic and hypolipidaemic properties in streptozotocin-induced diabetic rats. Inhibition of thromboxane synthase in vitro reduces platelet aggregation tendency, contributing to an antithrombotic profile. [37][97]

Cardiotonic

Gingerols are established cardiotonic principles. [8]-Gingerol activates sarcoplasmic reticulum Ca²⁺-ATPase in guinea pig atrial muscle, producing positive inotropic effects without the toxicity of classical cardiac glycosides. [38][39]

Antimigraine

Ginger demonstrates efficacy in migraine through multiple mechanisms. Double-blind RCTs confirm ginger potentiates NSAID effect in acute migraine treatment and shows prophylactic activity. Sublingual feverfew–ginger combination reduces migraine symptoms in early-phase attacks. [40][75][76][77]

Cognitive Enhancement

Oral supplementation with Zingiber officinale extract improves cognitive function — specifically working memory and attention — in middle-aged healthy women in a placebo-controlled study. [41]

Antiviral

Broad antiviral activity documented: fresh ginger against RSV; sesquiterpenes against rhinovirus; activity against avian influenza H9N2, Chikungunya virus, HCV in vitro, Herpes simplex (including acyclovir-resistant strains), and influenza virus. β-Sesquiphellandrene is the key antiviral constituent. [47][48]

Antibacterial

Active against Bacillus subtilis, B. anthracis, Staphylococcus aureus, Salmonella typhi, Escherichia coli, and Proteus mirabilis in preclinical models. [49]

Antiparasitic (Molluscicide)

Shogaols and gingerols demonstrate molluscicidal activity and anti-schistosomiasis/bilharziasis activity in preclinical models — a pharmacological property of potential relevance in endemic tropical regions.

Antimutagenic

Gingerol and zingerone demonstrate antimutagenic activity in mutagenicity assays. Ginger also protects DNA against hydrogen peroxide-induced damage and inhibits nicotine-induced cancer cell migration. [29]

Anticancer

Ginger inhibits growth and modulates angiogenic factor secretion in ovarian cancer cells and hepatoma (HepG2) cells. 6-Gingerol and especially 6-shogaol are the principal anticancer constituents. Protection of the kidney against cisplatin-induced nephrotoxicity also demonstrated. [50][51][52]

Anti-allergic

Ginger extract in a randomised controlled trial was comparable to loratadine in the treatment of allergic rhinitis. Ginger also reduces allergic airway inflammation by suppressing Th2-mediated immune responses. [53]

Antitussive & Expectorant

Ginger demonstrates antitussive and expectorant activity, supporting traditional use for cough, bronchitis, and respiratory tract congestion. [54][55][56]

Bioavailability Enhancer

The presence of ginger in a formulation improves the bioavailability of co-administered herbal or pharmaceutical compounds — a recognised piperine-like effect attributed to β-sesquiphellandrene and related EO constituents. [57]

Metabolic Syndrome & Anti-obesity

Reviews confirm beneficial effects of ginger on obesity and metabolic syndrome through multiple mechanisms including thermogenesis, appetite suppression, lipid metabolism modulation, and insulin sensitisation. [72][73]

DNA Protection

Dietary spices including ginger protect against hydrogen peroxide-induced DNA damage in cell models and inhibit nicotine-induced cancer cell migration — antimutagenic and chemopreventive properties. [29]

Aromatherapy & Topical Use

Essential Oil Properties

The essential oil of ginger rhizome shares and extends the anti-inflammatory and antiemetic activity of the whole plant, with additional antifungal, immunostimulant, and topical analgesic properties.

Analgesic & Anti-inflammatory (Topical)

EO of ginger demonstrates antinociceptive and anti-inflammatory activity in experimental animal models. Topical application of ginger essential oil in a dermal formulation attenuates the severity of adjuvant arthritis in Lewis rats. [58][59][60][61]

Antifungal

In vitro activity of ginger EO against fluconazole-resistant and fluconazole-susceptible Candida spp. has been confirmed, suggesting potential in topical antifungal applications. [62]

Immunostimulant

Ginger EO demonstrates immunomodulatory activity, supporting both humoral and cell-mediated immune responses. It opposes immunosuppression in experimental models. [63]

Digestive Tonic & Antiemetic (EO)

The EO is stomachic, carminative, laxative, apéritif, and anti-nausea by inhalation. A three-EO mixture including ginger EO proved effective in postoperative nausea; inhalation alone shows mixed evidence for chemotherapy-induced nausea. [64][86][87]

Anti-ulcer (Synergy)

A fraction of ginger EO containing α-zingiberene, β-sesquiphellandrene, bisabolene, and curcumene demonstrates synergistic anti-ulcer activity — exemplifying pharmacological synergy between EO components. [65]

Antispasmodic, Antitussive & Expectorant

The EO contributes antispasmodic, antitussive, and expectorant activity, complementing whole-plant respiratory indications for cough, bronchitis, sinusitis, and chronic catarrh.

Sedative (High Dose)

High doses of ginger EO in mice induce behavioural and memory alterations due to antagonist activity on the central muscarinic cholinergic system — a dose-dependent sedative effect distinct from the stimulant properties of low doses. [66]

Arthritis & Musculoskeletal (Topical)

Massage with aromatic ginger and orange essential oil is effective for moderate-to-severe knee pain in the elderly. Swedish massage with aromatic ginger oil reduces chronic low back pain in older adults in an RCT. [89][90]

Sexual Tonic & Aphrodisiac

The EO is classified as a sexual tonic and aphrodisiac in traditional aromatherapy, with indications for male impotence and female frigidity, consistent with whole-plant spermatogenic and libido-stimulant properties.

Clinical Use

Clinical Indications

Ginger's clinical indications span gastroenterology, gynaecology, rheumatology, neurology, and metabolic medicine, with one of the broadest evidence bases in phytomedicine.

Nausea & Vomiting
Phytotherapy — Whole Plant
  • Postoperative nausea & vomiting — Systematic review of RCTs confirms ginger superior to placebo and as effective as metoclopramide. [9]
  • Chemotherapy-induced nausea — 2 g/day reduces nausea in multiple clinical trials; also effective against cisplatin-induced emesis. [67][68]
  • Pregnancy nausea (first trimester) — Systematic review and meta-analysis confirms safety and efficacy for pregnancy-associated nausea and vomiting; widely used despite precautionary EMA advice. [69][70][71]
  • Motion sickness — EMA-recognised indication; 750–2000 mg 30–60 min before travel for adults. [2]
  • Recommended when classical antiemetics are poorly tolerated — Good safety profile makes it suitable when metoclopramide, ondansetron, or promethazine cause adverse effects. [93]
Gastric & Metabolic
Phytotherapy — Whole Plant
  • Gastritis, dyspepsia, inappetence — Stomachic, digestive, and carminative; increases salivary flow and intestinal peristalsis. EMA-recognised traditional use. [5]
  • Gastric ulcer — Antiulcer and gastroprotective; in vitro activity against H. pylori. [11][12]
  • Type 2 diabetes — 1000–2000 mg/day powdered rhizome improves insulin sensitivity, reduces fasting glucose and HbA1c in multiple RCTs and meta-analyses. [32][33]
  • Metabolic syndrome & obesity — Thermogenic, appetite-modulating, insulin-sensitising effects beneficial in metabolic syndrome. [72][73]
Pain & Rheumatology
Phytotherapy & Essential Oil
  • Osteoarthritis knee pain — Ginger extract reduces knee pain in OA patients (RCT, Altman & Marcussen). Topical ginger EO massage also effective for knee pain in the elderly. [18][89]
  • Chronic rheumatic pain (topical) — Ointment based on dense ginger extract demonstrates anti-inflammatory and analgesic activity for topical use. [80]
  • Muscle pain (exercise-induced) — Ginger reduces muscle pain caused by eccentric exercise in a clinical study. [22]
  • Low back pain — Swedish massage with aromatic ginger oil reduces chronic low back pain in older adults in an RCT. [90]
  • Dysmenorrhoea — 500 mg 3× daily or 250 mg 3× daily for 3–5 days is as effective as ibuprofen or mefenamic acid for primary dysmenorrhoea; cinnamon–ginger combination also reduces PMS. [82][83][84][85]
Neurological, Respiratory & Other
Phytotherapy — Whole Plant & EO
  • Migraine — Meta-analysis confirms ginger efficacy in migraine treatment. Double-blind RCT confirms potentiation of NSAID; prophylactic RCT shows reduction of migraine frequency. Sublingual feverfew–ginger effective in early-phase attack. [75][76][78]
  • Allergic rhinitis & asthma — Ginger extract comparable to loratadine in allergic rhinitis RCT; reduces allergic airway inflammation via Th2 suppression. [53][81]
  • Cognitive decline prevention — Improves working memory and attention in healthy middle-aged women. [41]
  • Cough, bronchitis, sinusitis — Antitussive, expectorant, and antispasmodic (EO); used topically and by inhalation for respiratory tract conditions. [54][56]
  • Ovarian cancer (adjunctive) — 6-gingerol and 6-shogaol inhibit ovarian cancer cell growth and angiogenesis; preliminary evidence for adjunctive use under investigation. [51]
Pharmacology

Known & Presumed Mode of Action

Ginger's broad pharmacology emerges from convergent actions on prostaglandin synthesis, serotonin and dopamine receptor systems, NF-κB signalling, and TRPV1 channels.

COX/LOX Dual Inhibition — Prostaglandin & Leukotriene Suppression

Gingerols and gingerediones inhibit both cyclooxygenase (COX) and lipoxygenase (LOX) pathways, reducing prostaglandin and leukotriene synthesis. This dual inhibition — unlike NSAIDs which are primarily COX-selective — accounts for ginger's anti-inflammatory, antalgic, and antidysmenorrhoeic activity with a favourable gastric safety profile. [21]

5-HT3 & D2 Receptor Antagonism (Antiemetic)

Shogaols and gingerols act on dopamine D2 and serotonin 5-HT3 receptors — the same targets as classical antiemetics metoclopramide and ondansetron. Galanolactone (a diarylheptanoid from Chinese ginger) is a competitive 5-HT3 antagonist. This dual receptor activity explains the breadth of antiemetic efficacy across nausea subtypes. [9]

TRPV1 Channel Activation

Both gingerols and shogaols activate the TRPV1 (transient receptor potential vanilloid 1) channel — the nociceptor also targeted by capsaicin. This activation initially produces a burning sensation, then desensitises the receptor, generating counter-irritant analgesia. This mechanism contributes to topical analgesic, antipruritic, and thermogenic effects. [24]

NF-κB Modulation & Cytokine Regulation

Ginger's anti-inflammatory mechanism is linked to inhibition of Akt kinase and activation of NF-κB pathways, triggering release of anti-inflammatory cytokines while reducing pro-inflammatory cytokine production (TNF-α, IL-1β, IL-6). This pathway explains the broad spectrum of anti-inflammatory activity across articular, metabolic, and respiratory models. [20]

Insulin Sensitisation & Glycaemic Control

Ginger improves insulin sensitivity through multiple mechanisms including GLUT-4 upregulation, AMPK activation, and inhibition of hepatic glucose production. Stimulation of insulin secretion from pancreatic β-cells has also been demonstrated, accounting for the complementary fasting and postprandial glucose-lowering effects. [31][32]

Thromboxane Synthase Inhibition

Ginger inhibits thromboxane synthase in vitro, reducing thromboxane A2 production and thereby impeding platelet aggregation — an antithrombotic mechanism relevant to cardiovascular protection. Clinically, this effect is context-dependent: not observed at culinary doses in healthy subjects, but documented in subjects with high fat diets. [97][98][99]

Legal Status & Notes

Regulatory Status

French Pharmacopoeia — Liste A

The rhizome of Zingiber officinale is listed in the French Pharmacopoeia, Liste A, recognising it as a plant with established medicinal use in France for both internal and external applications.

EMA/HMPC — Herbal Monograph Revision 1 (2025)

The European Medicines Agency's HMPC published Revision 1 of the EU herbal monograph on Zingiber officinale Roscoe, rhizome (EMA/HMPC/885789/2022) on 7 May 2025, establishing both well-established use and traditional use categories. [2]

EU Traditional Herbal Medicinal Product

Ginger rhizome preparations meeting pharmacopoeial standards qualify for registration as Traditional Herbal Medicinal Products under EU Directive 2004/24/EC for the traditional indications of nausea, digestive complaints, and loss of appetite.

Quality & Standardisation Requirement

Due to significant compositional variability between geographical origins and processing methods, ginger dietary supplements require quantitative analytical control of gingerols and shogaols content before clinical use. [4]

Clinical Safety

Safety & Precautions

Ginger has a well-established safety profile with very few serious adverse effects. Key concerns are pharmacokinetic CYP interactions, anticoagulant interactions, and the nuanced pregnancy guidance.

⚠️

Adverse Effects & Toxicity

  • Generally non-toxic: Ginger is non-toxic and non-mutagenic at therapeutic doses. Iranian safety studies confirm no malformative or neonatal toxicity. An extensive evidence-based review confirms good tolerability across clinical populations.
  • GI discomfort: At high doses, heartburn, bloating, and mild GI irritation may occur, particularly with the essential oil in undiluted form.
  • EO dermocaustic risk: The essential oil is potentially irritant and dermocaustic when applied undiluted to skin. Always dilute to 1–3% in a carrier oil for topical use.
  • Allergic sensitisation (EO): Allergic sensitisation is possible with repeated topical EO application, as with other aromatic sesquiterpene-rich oils.
  • Cholelithiasis: Avoid in patients with gallstones — ginger's choleretic and cholagogue effects may provoke biliary colic.
🚫

Contraindications & Drug Interactions

  • Pregnancy — precautionary caution: EMA recommends avoiding ginger during pregnancy and lactation as a precaution, as animal reproduction toxicity data are insufficient. However, a meta-analysis found it safe and effective for pregnancy nausea, and it is very widely used clinically. Clinical judgement required. [71]
  • Anticoagulants (warfarin): Potential pharmacodynamic interaction via inhibition of platelet aggregation (thromboxane synthase inhibition). Patients on warfarin should monitor INR. Risk may be dose-dependent. [100]
  • CYP interactions: Ginger moderately induces CYP3A4, 2C19, 2D6, and 1A2, and P-glycoprotein. However, clinically significant drug interactions appear rare in practice. [94]
  • Antiplatelet drugs: Additive antiplatelet effects possible with aspirin, clopidogrel, and other antiplatelet agents, particularly at high doses or in high-fat dietary contexts. [95][96]
  • Gallstones: Contraindicated in cholelithiasis due to ginger's bile secretion-stimulating effects.
Clinical Disclaimer: This monograph is for educational and professional reference only. It does not constitute medical advice, diagnosis, or treatment guidance. Zingiber officinale preparations should be used under the supervision of a qualified healthcare provider. The Health Reference reviews content against current primary literature.
Common Questions

Frequently Asked Questions

Is ginger effective for nausea and vomiting?
Yes — ginger is among the most evidence-based natural antiemetics available. A systematic review of randomised clinical trials confirms it is superior to placebo and as effective as metoclopramide for postoperative nausea. Clinical trials also support its use for chemotherapy-induced nausea at 2 g/day, and a meta-analysis confirms safety and efficacy for pregnancy-related nausea. The mechanism involves shogaols and gingerols acting on dopamine D2 and serotonin 5-HT3 receptors — the same targets as classical antiemetic drugs. For motion sickness, 750–2000 mg of rhizome powder taken 30–60 minutes before travel is the EMA-endorsed adult dose.
Can ginger replace ibuprofen for menstrual pain?
Clinical evidence suggests comparable efficacy. A randomised controlled trial (Ozgoli et al., 2009) found that 250 mg of ginger powder three times daily was as effective as 250 mg of mefenamic acid or 400 mg of ibuprofen for primary dysmenorrhoea. A separate placebo-controlled trial confirmed 500 mg three times daily for 3–5 days from menstrual onset significantly reduces pain. The mechanism is inhibition of prostaglandin and leukotriene synthesis — the same biochemical pathway targeted by NSAIDs. While ginger may not be suitable for severe dysmenorrhoea, it is a clinically validated option for mild-to-moderate cases, particularly for patients who cannot tolerate NSAIDs.
Does ginger interact with blood-thinning medications?
Potentially yes, though the clinical risk is nuanced. Ginger inhibits thromboxane synthase in vitro, reducing platelet aggregation — but this effect was not observed in healthy subjects consuming culinary amounts (15 g raw or 40 g cooked ginger daily). However, in subjects with high fat diets, antiplatelet activity was documented. A pharmacokinetic drug interaction risk also exists via moderate CYP3A4, 2D6, 2C19, and 1A2 induction. The EMA notes few clinically significant drug interactions in practice. Patients on warfarin or other anticoagulants should nonetheless discuss regular ginger supplementation with their clinician and monitor INR.
What is the difference between fresh and dried ginger?
The chemical profile changes substantially between fresh and dried ginger. Fresh ginger is rich in gingerols — the primary pungent principles responsible for most anti-inflammatory and antiemetic activity. On drying and heating, gingerols dehydrate to form shogaols, which are more potent in several bioassays including anticancer activity and 5-HT3 antagonism. Fresh ginger also specifically retains antiviral activity against RSV that is not documented for dried preparations. For antiemetic and anti-inflammatory clinical use, standardised dried powders (assayed for gingerol/shogaol content) are preferred. For antiviral applications (especially respiratory), fresh ginger may be more relevant.
Is ginger safe during pregnancy?
This requires nuanced clinical judgement. The EMA recommends avoiding ginger during pregnancy and lactation as a precautionary measure, since animal reproductive toxicity data are insufficient to fully exclude risk. However, ginger is among the most widely used natural remedies for pregnancy nausea globally, and a systematic review and meta-analysis (Viljoen et al., 2014) found it both safe and effective for pregnancy-associated nausea and vomiting. Iranian safety studies also found no malformative or neonatal toxicity. Culinary amounts are generally considered safe. Therapeutic supplemental doses should be discussed with an obstetric healthcare provider, particularly in the first trimester.
Can ginger improve blood sugar control in diabetes?
Yes, with solid clinical evidence. Multiple RCTs and meta-analyses confirm that 1000–2000 mg/day of dried powdered ginger rhizome improves insulin sensitivity, stimulates insulin secretion, and reduces both fasting blood glucose and HbA1c in type 2 diabetic patients. A 2022 systematic review and meta-analysis specifically found significant reductions in fasting glucose and HbA1c. A 2026 RCT also confirmed impact on blood pressure and glucose in T2D patients with cardiovascular disease. Importantly, ginger does not appear to modify glycaemia in healthy non-diabetic individuals, indicating a disease-state-specific mechanism rather than a non-specific hypoglycaemic effect.
Primary Literature

Bibliography

↑1.Butin A. Le gingembre: de son utilisation ancestrale à un avenir prometteur. Thèse Sciences pharmaceutiques. Nancy. 2017. ⟨hal-01932085⟩
↑2.EMA, HMPC (2025). European Union herbal monograph on Zingiber officinale Roscoe, rhizome. Revision 1. EMA/HMPC/885789/2022, 07 May 2025.
↑3.Kuzia N et al. Antidiabetic and Anti-Inflammatory Potential of Zingiberaceae Plants in Dietary Supplement Interventions. Molecules. 2026;31(2):311.
PubMed PMID:41599361 →
↑4.Tao Y et al. Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry. J Agric Food Chem. 2009;57(21):10014–21.
PubMed PMID:19817455 →
↑5.O'Hara M et al. A review of 12 commonly used medicinal herbs. Arch Fam Med. 1998;7(6):523–536.
PubMed PMID:9821826 →
↑6.Ahmed S et al. Anti-emetic effects of bioactive natural products. Phytopharmacology. 2013;4(2):390–433.
↑7.Xia L et al. The Antiemetic Effect of Xiao-Ban-Xia-Tang Formula is Associated With Regulating CaM/CaMKII/ERK1/2 Signaling Pathway in Cisplatin and 1-phenylbiguanide Hydrochloride Induced Rat Pica Models. 2020.
↑8.Tian L et al. Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems. J Nat Med. 2020;74(2):353–370.
↑9.Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Br J Anaesth. 2000;84(3):367–71.
PubMed PMID:10793599 →
↑10.Sharma SS et al. Antiemetic efficacy of ginger (Zingiber officinale) against cisplatin-induced emesis in dogs. J Ethnopharmacol. 1997;57(2):93–96.
PubMed PMID:9254112 →
↑11.Khushtar M et al. Protective Effect of Ginger oil on Aspirin and Pylorus Ligation-Induced Gastric Ulcer model in Rats. Indian J Pharm Sci. 2009;71(5):554–558.
PubMed PMID:20502577 →
↑12.Mahady GB et al. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res. 2005;19(11):988–91.
PubMed PMID:16317658 →
↑13.Abdulaziz Bardi D et al. In Vivo Evaluation of Ethanolic Extract of Zingiber officinale Rhizomes for Its Protective Effect against Liver Cirrhosis. BioMed Res Int. 2013;2013:918460. PMID: 24396831.
↑14.Grzanna R, Lindmark L, Frondoza CG. Ginger — an herbal medicinal product with broad anti-inflammatory actions. J Med Food. 2005;8(2):125–132.
PubMed PMID:16117603 →
↑15.Penna SC, Medeiros MV. Anti-inflammatory effect of the hydralcoholic extract of Zingiber officinale rhizomes on rat paw and skin edema. Phytomed. 2003;10(5):381–385.
PubMed PMID:12834002 →
↑16.Thomson M et al. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids. 2002;67(6):475–478.
PubMed PMID:12468270 →
↑17.Shen CL, Hong KJ, Kim SW. Effects of ginger on decreasing the production of inflammatory mediators in sow osteoarthrotic cartilage explants. J Med Food. 2003;6(4):323–8.
PubMed PMID:14977440 →
↑18.Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001;44(11):2531–8.
PubMed PMID:11710709 →
↑19.Ballester P et al. Effect of Ginger on Inflammatory Diseases. Molecules. 2022;27(21):7223.
PubMed PMID:36364048 →
↑20.Ayustaningwarno F et al. A critical review of Ginger's antioxidant, anti-inflammatory, and immunomodulatory activities. Front Nutr. 2024;11:1364836.
PubMed PMID:38903613 →
↑21.Srivastava KC, Mustafa T. Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypotheses. 1992;39(4):342–8.
PubMed PMID:1494322 →
↑22.Black CD et al. Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. J Pain. 2010;11(9):894–903.
PubMed PMID:20418184 →
↑23.Terry R et al. The use of ginger (Zingiber officinale) for the treatment of pain: a systematic review of clinical trials. Pain Med. 2011;12(12):1808–18.
PubMed PMID:22054010 →
↑24.Vriens J, Nilius B, Vennekens R. Herbal compounds and toxins modulating TRP channels. Curr Neuropharmacol. 2008;6(1):79–96.
PubMed PMID:19305789 →
↑25.Suciyati SW, Adnyana IK. Red ginger (Zingiber officinale Roscoe var rubrum): A review. Pharmacologyonline. 2017;2:60–65.
↑26.Lakshmi BVS, Sudhakar M. Attenuation of acute and chronic restraint stress-induced perturbations in experimental animals by Zingiber officinale Roscoe. Food Chem Toxicol. 2010;48(2):530–535.
↑27.He SM et al. Disposition pathways and pharmacokinetics of herbal medicines in humans. Curr Med Chem. 2010;17(33):4072–113.
PubMed PMID:20939821 →
↑28.Ulbricht C et al. An evidence-based systematic review of herb and supplement interactions by the Natural Standard Research Collaboration. Expert Opin Drug Saf. 2006;5(5):719–28.
PubMed PMID:16907661 →
↑29.Jayakumar R, Kanthimathi MS. Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration. Food Chemistry. [Elsevier]
↑30.Qureshi S et al. Studies on herbal aphrodisiacs used in Arab system of medicine. Am J Chin Med. 1989;17(1–2):57–63.
PubMed PMID:2589237 →
↑31.Akhani SP, Vishwakarma SL, Goyal RK. Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. J Pharm Pharmacol. 2004;56(1):101–105.
PubMed PMID:14980006 →
↑32.Carvalho GCN et al. Effectiveness of Ginger in Reducing Metabolic Levels in People with Diabetes: A Randomized Clinical Trial. Rev Lat Am Enferm. 2020;28:e3369.
PubMed PMID:33053078 →
↑33.Ebrahimzadeh A et al. The Effect of Ginger Supplementation on Metabolic Profiles in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Complement Ther Med. 2022;65:102802.
PubMed PMID:35031435 →
↑34.Rostamkhani H et al. The effect of Zingiber officinale on prooxidant-antioxidant balance and glycemic control in diabetic patients with ESRD undergoing hemodialysis: a double-blind randomized control trial. BMC Complement Med Ther. 2023;23(1):52.
PubMed PMID:36800950 →
↑35.Schumacher JC et al. The Effect of Oral Supplementation of Ginger on Glycemic Control of Patients with Type 2 Diabetes Mellitus — A Systematic Review and Meta-Analysis. Clin Nutr ESPEN. 2024;63:615–622. PMID: 39053695.
↑36.Dahy A et al. Impact of Ginger Supplementation on Blood Pressure and Glucose Levels in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease. Georgian Med News. 2026;(370):188–192. PMID: 41804150.
↑37.Al-Amin ZM et al. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br J Nutr. 2006;96(4):660–6.
PubMed PMID:17010224 →
↑38.Shoji N et al. Cardiotonic principles of ginger (Zingiber officinale Roscoe). J Pharm Sci. 1982;71(10):1174–1175.
↑39.Kobayashi M et al. Cardiotonic action of [8]-gingerol, an activator of the Ca++-pumping adenosine triphosphatase of sarcoplasmic reticulum, in guinea pig atrial muscle. J Pharmacol Exp Ther. 1988;246(2):667–73.
PubMed PMID:2457078 →
↑40.Mustafa T, Srivastava KC. Ginger (Zingiber officinale) in migraine headache. J Ethnopharmacol. 1990;29(3):267–73.
PubMed PMID:2214812 →
↑41.Saenghong N et al. Zingiber officinale improves cognitive function of the middle-aged healthy women. Evid-Based Complement Altern Med. 2012.
↑42.Chang JS et al. Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. J Ethnopharmacol. 2013;145(1):146–151.
↑43.Denyer CV et al. Isolation of Antirhinoviral Sesquiterpenes from Ginger (Zingiber officinale). J Nat Prod. 1994;57(5):658–662.
↑44.Ahmed I et al. Anti-avian influenza virus H9N2 activity of aqueous extracts of Zingiber officinalis (Ginger) and Allium sativum (Garlic) in chick embryos. Pak J Pharm Sci. 2017;30(4):1341–1344.
↑45.Kaushik S et al. Anti-viral activity of Zingiber officinale (Ginger) ingredients against the Chikungunya virus. VirusDisease. 2020.
↑46.El-Wahab A et al. In vitro study of the antiviral activity of Zingiber officinale. Planta Med. 2009;75.
↑47.Schnitzler P, Koch C, Reichling J. Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood. Antimicrob Agents Chemother. 2007;51(5):1859–62.
PubMed PMID:17353250 →
↑48.Wang X et al. Anti-influenza agents from plants and traditional Chinese medicine. Phytother Res. 2006;20(5):335–41.
PubMed PMID:16619359 →
↑49.Sharma A et al. Antibacterial Activity of Medicinal Plants Against Pathogens causing Complicated Urinary Tract Infections. Indian J Pharm Sci. 2009;71(2):136–9.
PubMed PMID:20336211 →
↑50.Abdullah S. Antiproliferative, Antioxidant and Apoptosis Effects of Zingiber officinale and 6-Gingerol on HepG2 Cells. Asian J Biochem. 2010;2(6):421–426.
↑51.Rhode J et al. Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells. BMC Complement Altern Med. 2007;7:44.
↑52.Ajith TA, Nivitha V, Usha S. Zingiber officinale Roscoe alone and in combination with α-tocopherol protect the kidney against cisplatin-induced acute renal failure. Food Chem Toxicol. 2007;45(6):921–927.
↑53.Yamprasert R et al. Ginger extract versus Loratadine in the treatment of allergic rhinitis: a randomized controlled trial. BMC Complement Med Ther. 2020;20(1):119.
PubMed PMID:32312261 →
↑54.Sultana S et al. Cough suppressant herbal drugs: A review. Int J Pharm Sci Invent. 2016;5(5):15–28.
↑55.Ndagijimana A et al. Phytochemical Review on Ocimum sanctum, Zingiber officinale, Rosmarinus officinalis and Eucalyptus globulus for their antitussive and antioxidant activities. J Chem Pharm Res. 2016:243–250.
↑56.Pai V et al. Phytopharmacological Review of a Food Supplement Zingiber officinale Roscoe (Zingiberaceae). Curr Nutr Food Sci. 2022;18.
↑57.Dudhatra GB et al. A comprehensive review on pharmacotherapeutics of herbal bioenhancers. ScientificWorldJournal. 2012;2012:637953.
PubMed PMID:23028251 →
↑58.Vendruscolo A et al. Antiinflammatory and antinociceptive activities of Zingiber officinale Roscoe essential oil in experimental animal models. Indian J Pharmacol. 2006;38:58–9.
↑59.Melo GA et al. Inhibitory effects of ginger (Zingiber officinale Roscoe) essential oil on leukocyte migration in vivo and in vitro. J Nat Med. 2011;65(1):241.
↑60.Jeena K, Liju VB, Kuttan R. Antioxidant, Anti-Inflammatory and Antinociceptive Activities of Essential Oil From Ginger. Indian J Physiol Pharmacol. 2013;57(1):51–62.
PubMed PMID:24020099 →
↑61.Komeh-Nkrumah SA et al. Topical dermal application of essential oils attenuates the severity of adjuvant arthritis in Lewis rats. Phytother Res. 2012;26(1):54–59.
↑62.Pozzatti P et al. In vitro activity of essential oils extracted from plants used as spices against fluconazole-resistant and fluconazole-susceptible Candida spp. Can J Microbiol. 2008;54(11):950–6.
PubMed PMID:18997851 →
↑63.Carrasco FR et al. Immunomodulatory activity of Zingiber officinale Roscoe, Salvia officinalis L. and Syzygium aromaticum L. essential oils. J Pharm Pharmacol. 2009;61(7):961–7.
PubMed PMID:19589240 →
↑64.de Pradier E. Essai d'un mélange de trois huiles essentielles dans le traitement des nausées et vomissements postopératoires. Phytothérapie. Vol. 4, No. 4:181–187.
↑65.Williamson EM. Synergy and other interactions in phytomedicines. Phytomedicine. 2001;8(5):401–9.
PubMed PMID:11695885 →
↑66.Felipe CF et al. Alterations in behavior and memory induced by the essential oil of Zingiber officinale Roscoe (ginger) in mice are cholinergic-dependent. J Med Plants Res. 2008;2:163–170.
↑67.Haniadka R et al. Zingiber officinale (ginger) as an anti-emetic in cancer chemotherapy: a review. J Altern Complement Med. 2012;18(5):440–4.
PubMed PMID:22540971 →
↑68.Marx WM et al. Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review. Nutr Rev. 2013;71(4):245–54.
PubMed PMID:23550785 →
↑69.Stanisiere J, Mousset PY, Lafay S. How safe is ginger rhizome for decreasing nausea and vomiting in women during early pregnancy? Foods. 2018;7(4):50.
↑70.Lete I, Alluέ J. The effectiveness of ginger in the prevention of nausea and vomiting during pregnancy and chemotherapy. Integr Med Insights. 2016;11:IMI-S36273.
↑71.Viljoen E et al. A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J. 2014;13:20.
↑72.Wang J et al. Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review. Ann N Y Acad Sci. 2017;1398(1):83–98.
PubMed PMID:28505392 →
↑73.Ebrahimzadeh Attari V et al. A systematic review of the anti-obesity and weight lowering effect of ginger (Zingiber officinale Roscoe) and its mechanisms of action. Phytother Res. 2018;32(4):577–585.
PubMed PMID:29193411 →
↑74.Mustafa T, Srivastava KC. Ginger (Zingiber officinale) in migraine headache. J Ethnopharmacol. 1990;29(3):267–273.
↑75.Chen L, Cai Z. The efficacy of ginger for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2021;46:567–571.
PubMed PMID:33293189 →
↑76.Martins LB et al. Double-blind placebo-controlled randomized clinical trial of ginger addition in migraine acute treatment. Cephalalgia. 2019;39(1):68–76.
PubMed PMID:29768938 →
↑77.Martins LB et al. Double-blind placebo-controlled randomized clinical trial of ginger in the prophylactic treatment of migraine. Cephalalgia. 2020;40(1):88–95.
PubMed PMID:31398997 →
↑78.Cady RK et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic™ M) in the treatment of migraine. Headache. 2011;51(7):1078–86.
PubMed PMID:21631494 →
↑79.Cady RK et al. Gelstat Migraine (sublingually administered feverfew and ginger compound) for acute treatment of migraine when administered during the mild pain phase. Med Sci Monit. 2005;11(9):PI65–9.
PubMed PMID:16127373 →
↑80.Kravchenko I et al. Anti-inflammatory and analgesic activity of ointment based on dense ginger extract (Zingiber officinale). J Herbmed Pharmacol. 2019;8(2):126–132.
↑81.Khan AM et al. Zingiber officinale ameliorates allergic asthma via suppression of Th2-mediated immune response. Pharm Biol. 2015;53(3):359–367.
↑82.Rahnama P et al. Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial. BMC Complement Altern Med. 2012;12:92.
PubMed PMID:22781186 →
↑83.Ozgoli G, Goli M, Moattar F. Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. J Altern Complement Med. 2009;15(2):129–32.
PubMed PMID:19216660 →
↑84.Kashefi F et al. Comparison of the effect of ginger and zinc sulfate on primary dysmenorrhea: a placebo-controlled randomized trial. Pain Manag Nurs. 2014;15(4):826–33.
PubMed PMID:24559600 →
↑85.Ebrahimi Azmoudeh B, Habibian M, Askari B. The Effectiveness of the Combination of Cinnamon and Ginger with Exercise Training in the Treatment of Dysmenorrhea and Premenstrual Syndrome. Iran J Nurs. 2019;32(121):68–81.
↑86.Karaman S et al. A randomized placebo-controlled study of aromatherapy for the treatment of postoperative nausea and vomiting. Complement Ther Med. 2019;42:417–421.
PubMed PMID:30670276 →
↑87.Lua PL, Salihah N, Mazlan N. Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer. Complement Ther Med. 2015;23(3):396–404.
PubMed PMID:26051575 →
↑88.Evans A et al. The Use of Aromatherapy to Reduce Chemotherapy-Induced Nausea in Children With Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial. J Pediatr Oncol Nurs. 2018;35(6):392–398.
PubMed PMID:29947285 →
↑89.Yip YB, Tam AC. An experimental study on the effectiveness of massage with aromatic ginger and orange essential oil for moderate-to-severe knee pain among the elderly in Hong Kong. Complement Ther Med. 2008;16(3):131–8.
PubMed PMID:18534325 →
↑90.Sritoomma N et al. The effectiveness of Swedish massage with aromatic ginger oil in treating chronic low back pain in older adults: a randomized controlled trial. Complement Ther Med. 2014;22(1):26–33.
PubMed PMID:24559813 →
↑91.EMA, HMPC. Community herbal monograph on Zingiber officinale Roscoe, rhizoma. [Reference cited in source; full details in EMA monograph ref 2]
↑92.Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res. 2018;32(6):985–995.
PubMed PMID:29480523 →
↑93.Giacosa A et al. Can nausea and vomiting be treated with ginger extract? Eur Rev Med Pharmacol Sci. 2015;19(7):1291–6.
PubMed PMID:25912592 →
↑94.Qiu JX et al. Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studies. Drug Des Devel Ther. 2015;9:841–66.
PubMed PMID:25733806 →
↑95.Collège des médecins & Ordre des pharmaciens du Québec. Les produits de santé naturels, pour mieux conseiller les patients. Document de référence. 2004.
↑96.Akram M et al. Zingiber officinale roscoe (A medicinal plant). Pakistan J Nutr. 2011;10(4):399–400.
↑97.Backon J. Ginger: inhibition of thromboxane synthetase and stimulation of prostacyclin: relevance for medicine and psychiatry. Med Hypotheses. 1986;20(3):271–8.
PubMed PMID:3528776 →
↑98.Janssen PL et al. Consumption of ginger (Zingiber officinale roscoe) does not affect ex vivo platelet thromboxane production in humans. Eur J Clin Nutr. 1996;50(11):772–4.
PubMed PMID:8933126 →
↑99.Verma SK et al. Effect of ginger on platelet aggregation in man. Indian J Med Res. 1993;98:240–2.
PubMed PMID:8119760 →
↑100.Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57(13):1221–7.
PubMed PMID:10902065 →
↑101.Shin IS et al. Subacute toxicity and stability of Soshiho-tang, a traditional herbal formula, in Sprague-Dawley rats. BMC Complement Altern Med. 2012;12:266.

Additional Clinical & Reference Literature

Wichtl M, Anton R. Plantes thérapeutiques: Tradition, pratique officinale, science et thérapeutique. Ed. Tec & Doc. Cachan. 1999. p. 610.
Tsai et al. Antioxidant and anti-inflammatory activities of several commonly used spices. Journal of Food Science. 2005;70(1):93–97.
Mascolo N et al. Ethnopharmacologic investigation of ginger (Zingiber officinale). J Ethnopharmacol. 1989;27(1–2):129–140.
Plengsuriyakarn T et al. Anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of Thai medicinal plants in animal models. BMC Complement Altern Med. 2012.