Phycology · Clinical Nutrition

Spirulina

Arthrospira platensis Gomont — A microscopic spiral cyanobacterium and one of Earth's most nutrient-dense organisms, delivering immunostimulant, antioxidant, neuroprotective, and anti-allergic effects through phycocyanin, high-molecular-weight polysaccharides, and a complete amino acid matrix.

43 Primary Refs
13 Properties
Alga Parts Used
✦ Researched
Last Updated
Primary Source Wikiphyto · NCBI PubMed
Class Cyanophyceae
Researched ✦ · Cyanophyceae

Biological Overview

Arthrospira platensis is not a plant — it is a cyanobacterium, one of Earth's oldest photosynthetic organisms. With 60–70% protein content exceeding that of meat, a complete essential amino acid profile, and a unique combination of phycocyanin, immolina polysaccharides, and gamma-linolenic acid, it is among the most nutrient-dense organisms known to science. Clinical evidence supports its use across immunity, allergy, neuroprotection, malnutrition, and exercise recovery.

Key ActivesPhycocyanin, Immolina, GLA, Beta-carotene
Primary TargetsImmune, CNS, Musculoskeletal, Haematopoietic
Key MechanismTLR2 activation · COX-2 inhibition · ROS scavenging
Protein Content60–70% — exceeds meat
Scientific Classification

Taxonomy & Classification

Latin Name
Arthrospira platensis Gomont
Synonym
Spirulina platensis (Gomont) Geitler
Other Species
Arthrospira maxima; Arthrospira fusiformis
Class
Cyanophyceae (Blue-green alga)
Family
Pseudanabaenaceae
Common Name
Spirulina
Type
Cyanobacterium (prokaryote)
Parts Used
Whole alga (entire organism)
Morphology & Distribution

Description & Habitat

Spirulina consists of microscopic, mobile, multicellular filaments arranged in a characteristic open helix — the spiral form that gives it its common name. The filaments are non-branching and measure only a few micrometres in diameter, visible only under microscopy as blue-green spiral threads.

Spirulina platensis (now Arthrospira platensis) originates from the alkaline lakes of Chad in central Africa; Spirulina maxima from Lake Texcoco in Mexico — both environments characterised by high pH, high salinity, and intense sunlight that favour cyanobacterial growth and suppress competing organisms.

Today, Spirulina is produced almost entirely through controlled basin cultivation worldwide. This controlled environment allows precise monitoring of contamination risks — the key quality determinant for safe commercial Spirulina.

Morphological & Ecological Profile

Form
Microscopic spiral filaments
Structure
Multicellular, non-branching
Colour
Blue-green (phycocyanin + chlorophyll)
Natural habitat
Warm alkaline lakes
Origin — platensis
Lake Chad, central Africa
Origin — maxima
Lake Texcoco, Mexico
Production
Controlled basin cultivation
Algae class
Blue (Cyanophyceae) — smallest & oldest
Ethnobotany & Traditional Use

History & Tradition

Africa — Kanem Empire

Kanembou Tradition

The Kanembou people of Chad have harvested Spirulina from Lake Chad for centuries, drying it into flat cakes called dihe used as a protein-rich food staple and traded across the Sahel region. This represents one of the longest documented uses of a microalgae as human food.

Pre-Columbian Americas

Aztec & Inca Use

Spanish conquistadores recorded consumption of a blue-green algae harvested from Lake Texcoco by Aztec and pre-Inca peoples — almost certainly Arthrospira maxima. It was processed into dry cakes and sold in markets, attesting to its recognised nutritional and energetic value in ancient Mesoamerica.

Modern Recognition

WHO & Global Nutrition

Spirulina has been formally endorsed by WHO and UNICEF as a practical intervention against childhood malnutrition in resource-limited settings. Clinical trials in Africa demonstrate that 10 g/day for 4–6 weeks can reverse severe protein-energy malnutrition in children, with additional benefits documented in HIV-positive populations. [5][6]

Therapeutic Material

Parts Used & Available Forms

🌊

Whole Alga — Dried Biomass

The entire organism is used. Spirulina is harvested from cultivation basins, spray-dried or freeze-dried at low temperature to preserve phycocyanin and heat-sensitive nutrients, then processed into powder, tablet, or capsule form. Freeze-drying (lyophilisation) preserves the broadest range of bioactive constituents.

⚠ Quality is everything

The safety and efficacy of Spirulina depend entirely on cultivation source and quality control. Contamination with cyanotoxins, heavy metals, or pathogenic bacteria is a documented real-world risk. Only purchase products from certified, third-party tested manufacturers with verified clean-water cultivation and microcystin testing.

Available Galenical Forms

Powder Most versatile form. Can be added to water, juice, or smoothies. Highest bioavailability when dissolved.
Oral
Tablets Compressed whole-alga tablets. Convenient for precise daily dosing. Standard pharmacopoeial form.
Oral
Capsules (Gelatin or Vegetable) Encapsulated powder. Preferred by those who dislike the taste or smell of raw powder.
Oral
Lyophilised Extract Freeze-dried to preserve maximum phycocyanin and enzymatic activity. Used in clinical studies.
Research
Clinical Dosing

Usual Dosages

General supplementation range is 2–10 g/day. Clinical malnutrition trials use 10 g/day for 4–6 weeks. Anti-allergic rhinitis studies used 2 g/day. Anti-obesity trial used 1 g/day.

Indication Dose Duration Evidence Level
General supplementation / nutrition 2–10 g/day Ongoing Traditional / nutritional consensus
Severe childhood malnutrition 10 g/day 4–6 weeks Clinical trials in Africa [5][6]
Allergic rhinitis 2 g/day Clinical trial duration RCT vs placebo and cetirizine [17][18]
Obesity adjuvant 1 g/day Randomised trial duration RCT (double-blind, placebo-controlled) [9]
Exercise performance / recovery Varies by study Per training period Clinical evidence [19][20]
Biochemical Profile

Composition

At 60–70% protein with all essential amino acids, Spirulina is the most protein-dense food known — richer than meat, soy, or any other plant source. Its phycocyanin pigment and immolina polysaccharide are the primary pharmacological drivers.

Key Bioactive Constituents

Phycocyanin (C-phycocyanin) Signature blue phycobiliprotein + water-soluble photosynthetic pigment. Potent antioxidant, anti-inflammatory, and neuroprotectant. The defining bioactive of Spirulina. [24][25]
Key Active
Immolina (High-MW Polysaccharide) High-molecular-weight beta-glucan polysaccharide. Activates TLR2 on monocytes; upregulates TNF-alpha, IL-1beta, COX-2. Primary immunostimulant fraction. [13][15]
Immunostimulant
Proteins (Complete) 60–70% by dry weight. Contains all essential amino acids including branched-chain amino acids (leucine, isoleucine, valine). Highest protein density of any known food source. [1]
60–70%
Gamma-Linolenic Acid (GLA) 1000 mg/100 g. Essential omega-6 fatty acid with anti-inflammatory properties; rare in food sources, usually requiring evening primrose or borage oil.
1000 mg/100g
Beta-carotene (Provitamin A) 85 mg/100 g (total provitamin A 140 mg). Among the richest dietary sources of beta-carotene; antioxidant and immunomodulatory.
85 mg/100g
Iron 81 mg/100 g — exceptional bioavailable iron content supporting haematopoiesis and correction of iron-deficiency anaemia.
81 mg/100g
Pseudovitamin B12 ⚠ Contains corrinoid compounds that are inactive as B12 in humans. Not a reliable B12 source — especially for vegetarians. [2][3]
⚠ Inactive

Vitamins per 100 g

VitaminAmount
Provitamin A (β-carotene)140 mg
B1 Thiamine3.5 mg
B2 Riboflavin4 mg
B3 Nicotinamide14 mg
B6 Pyridoxine0.8 mg
B9 Folic acid10 µg
Vitamin E Tocopherol10 mg
Vitamin K Menadione2.24 mg
GLA (Gamma-Linolenic Acid)1000 mg

Minerals per 100 g

MineralAmount
Iron81 mg
Phosphorus1000 mg
Magnesium285 mg
Sodium600 mg
Calcium215 mg
Iodine200 µg
Zinc1.6 mg
Selenium13.8 µg

Plant Properties — Pharmacodynamics

Whole-alga biological activities with primary literature citations

13 Properties RCT Evidence 43 Primary Refs

Nutritional & Anti-malnutrition

Clinical trials confirm 10 g/day for 4–6 weeks reverses severe protein-energy malnutrition in children. Used in Africa alongside antiretrovirals in HIV patients, delivering weight gain, CD4 lymphocyte increase, and reduction of opportunistic infections. [5][6][7][8]

Immunostimulant & Immunomodulant

Three high-molecular-weight polysaccharide fractions — including Immolina — demonstrate potent immunostimulatory activity via TLR2-dependent monocyte activation. Enhances NK cell activity, stimulates erythropoiesis, and may improve immune function suppressed by anticancer drugs. [13][14][15][16]

Anti-allergic

Spirulina is superior to placebo in treating allergic rhinitis symptoms in a randomised clinical trial, and comparable to or more effective than cetirizine in a second clinical study. Mechanism: suppression of Th2 cell differentiation via IL-4 inhibition. [17][18][38]

Antioxidant

Multiple fractions demonstrate significant antioxidant activity. Aqueous extracts protect against free radical-induced cell death. Selenium-containing allophycocyanin inhibits AAPH-induced ROS generation in human erythrocytes. C-phycocyanin directly scavenges reactive oxygen species. [21][22][23]

Anti-inflammatory

C-phycocyanin demonstrates significant anti-inflammatory activity in multiple animal models, inhibiting COX-2 and downstream prostaglandin synthesis. Immolina upregulates pro-inflammatory cytokines at immunostimulant doses while paradoxically modulating the overall inflammatory response. [24][25][26]

Neuroprotective

Protects SH-SY5Y neuroblastoma cells against iron-induced toxicity. Reduces ischaemia-reperfusion brain damage. Provides neuroprotection in an alpha-synuclein model of Parkinson's disease by reducing microglial activation. Polysaccharide fraction specifically protects dopaminergic neurons against MPTP-induced damage. [27][28][29][30][31]

Neural Stem Cell Proliferator

Spirulina promotes neural stem cell genesis and protects against LPS-induced declines in neural stem cell proliferation. Combined with blueberry, green tea, catechin, carnosine, and vitamin D3 it promotes proliferation of human stem cells from bone marrow. [33][34]

Exercise Performance & Recovery

Supplementation improves oxygen uptake during arm cycling exercise. Prevents skeletal muscle oxidative damage under exercise-induced oxidative stress, improves antioxidant enzyme activity, reduces oxidative stress, and improves fat utilisation during exercise. [19][20]

Anti-obesity

A randomised double-blind placebo-controlled trial found Spirulina platensis significantly improves anthropometric indices and lipid profile in obese individuals at 1 g/day, and reduces serum VEGF — a marker of adipose tissue vascularisation and obesity-related angiogenesis. [9]

Haematopoietic & Anti-anaemic

Stimulates erythropoiesis (red blood cell production) in bone marrow. Exceptional iron content (81 mg/100 g) directly addresses iron-deficiency anaemia. Indicated as an adjuvant in haematological cancers and states of bone marrow depression. [37]

Testicular Protective

Spirulina platensis protects rat testes against mercury chloride-induced oxidative damage, improving sperm quality, testicular morphology, and oxidative stress markers — confirming a protective role against heavy metal reproductive toxicity. [35]

Anti-urolithiatic & Renal Protective

Phycocyanin from Spirulina prevents calcium oxalate renal cell injury in vitro and in vivo, demonstrating prophylactic anti-urolithiatic activity with antioxidant protection of renal tissue against oxalate-mediated damage. [36]

Anticancer Adjuvant & Atherosclerosis Prevention

Used as an adjuvant in cancer, cellular ageing, and infectious disease via its major role in bone marrow function. Silicon-enriched Spirulina improves arterial remodelling and function in hypertensive rats, suggesting benefit in atherosclerosis prevention. [37][39]

Clinical Use

Clinical Indications

Indications span nutritional deficiency, immune disorders, allergy, neurology, sports medicine, and haematology — backed by clinical trials and primary research.

🍃
Nutrition & Metabolic
Phytotherapy — Whole Alga
  • Malnutrition & undernutrition — Clinically validated at 10 g/day for 4–6 weeks in severe childhood protein-energy malnutrition. [5][6]
  • HIV nutritional support — Improves weight, CD4 count, and reduces opportunistic infections as adjunct to antiretroviral therapy. [8]
  • Obesity (adjuvant) — RCT demonstrates improved anthropometric indices, lipid profile, and VEGF reduction at 1 g/day. [9]
  • Asthenia & convalescence — Rich B-vitamin complex, iron, and complete protein profile support energy restoration and recovery.
  • Iron-deficiency anaemia — Highest dietary iron content (81 mg/100 g) with co-present vitamin C for enhanced bioavailability.
  • Atherosclerosis prevention — Silicon-enriched Spirulina improves arterial remodelling in hypertensive models. [39]
🛡️
Immune & Allergic
Phytotherapy — Whole Alga
  • Allergic rhinitis — treatment & prevention — Effective vs placebo and non-inferior to cetirizine in clinical trials. Suppresses Th2-mediated IL-4 production. [17][18]
  • Immune depression — Indicated in states of weakened immunity including post-chemotherapy immune suppression. [16]
  • Anticancer adjuvant — Supports haematopoiesis and immune function during and after cancer treatment. [37]
  • Infectious disease (adjuvant) — Immunostimulant activity via TLR2 monocyte activation; macrophage and NK cell enhancement. [13][14]
🧠
Neurological & Neuroprotective
Phytotherapy — Whole Alga
  • Parkinson's disease (adjuvant) — Neuroprotection of dopaminergic neurons documented via reduced microglial activation in animal models. [30][31]
  • Ischaemia-reperfusion injury — Reduces ischaemic brain damage in dietary supplementation studies. [29]
  • Cognitive ageing & neuroregeneration — Promotes neural stem cell proliferation; combined formulas show bone marrow stem cell stimulation. [33][34]
  • Cellular ageing — Antioxidant and anti-inflammatory activity via phycocyanin slows oxidative stress-driven cellular ageing. [28]
💪
Sports, Renal & Reproductive
Phytotherapy — Whole Alga
  • Exercise performance & recovery — Improves VO2 uptake, reduces muscle oxidative damage, enhances fat utilisation during exercise. [19][20]
  • Urinary lithiasis prevention — Phycocyanin protects renal cells against calcium oxalate injury; anti-urolithiatic and renal-protective. [36]
  • Heavy metal reproductive toxicity — Protects testicular tissue against mercury-induced oxidative damage. [35]
Pharmacology

Known & Presumed Mode of Action

🔵

C-Phycocyanin — ROS Scavenging & COX-2 Inhibition

C-phycocyanin directly scavenges hydroxyl radicals, peroxyl radicals, and singlet oxygen. It simultaneously inhibits cyclooxygenase-2 (COX-2) and downstream prostaglandin synthesis, producing anti-inflammatory effects comparable to standard NSAIDs without gastric toxicity. This dual mechanism accounts for both antioxidant and anti-inflammatory properties. [24][25][26]

🛡️

Immolina — TLR2-Dependent Immune Activation

The Immolina polysaccharide fraction activates monocytes via Toll-like receptor 2 (TLR2), triggering upregulation of TNF-alpha, IL-1beta, and COX-2 in human THP-1 monocytic cells. This TLR2-dependent pathway is a key mechanism of innate immune stimulation, explaining the documented immunostimulant and anti-infective properties. [13][15]

🌿

Th2 Suppression — Anti-allergic Mechanism

Spirulina inhibits IL-4 production, suppressing Th2 cell differentiation — the central driver of IgE-mediated allergic responses including allergic rhinitis, asthma, and atopic dermatitis. By shifting the Th1/Th2 balance toward Th1 dominance, it reduces allergic sensitisation and symptom severity. [38]

🧬

Microglial Modulation — Neuroprotection

Spirulina reduces alpha-synuclein-induced microglial activation — a key pathological mechanism in Parkinson's disease where overactivated microglia destroy dopaminergic neurons. The polysaccharide fraction independently protects dopaminergic neurons in MPTP-induced Parkinson's models by reducing microglial-mediated neuroinflammation. [30][31][32]

⚗️

CYP450 Weak Inhibition — Drug Interaction Basis

Spirulina weakly inhibits CYP2E1, CYP1A2, and CYP2C6 hepatic microsomal enzymes — the mechanistic basis for its pharmacokinetic drug interactions. This inhibition could theoretically increase plasma levels of drugs metabolised by these isoenzymes, though the clinical magnitude depends on dose and concomitant medication. [41]

🩸

Haematopoietic Stimulation

Spirulina stimulates erythropoiesis in bone marrow — increasing red blood cell production. This effect, combined with its exceptional bioavailable iron content (81 mg/100 g) and B-vitamin complex, provides a multi-mechanism basis for its anti-anaemic and haematological adjuvant applications. [16][37]

Clinical Safety

Safety & Precautions

Spirulina itself is neither mutagenic nor genotoxic, and is not contraindicated in pregnancy at moderate doses. The principal safety risks arise from product contamination — not from the alga itself — and from pharmacokinetic drug interactions.

⚠️

Adverse Effects & Toxicity

  • Not mutagenic or genotoxic: Spirulina is confirmed non-mutagenic and non-genotoxic in standard toxicological assessments.
  • Digestive disturbance: Nausea and gastrointestinal discomfort, particularly at higher doses or on initiation. Starting at lower doses and titrating up reduces this.
  • Allergy — rare: A first case of spirulina allergy in a 13-year-old child has been reported, confirming the possibility of sensitisation, though extremely rare. [40]
  • Pseudovitamin B12 risk: Cannot substitute for genuine B12 supplementation — especially in vegetarians and vegans. May mask B12 deficiency by appearing active in serum tests. [2][3]
  • Contamination risks (product-dependent): Pathogenic bacteria (Staphylococcus, Streptococcus, Enterobacter, Proteus), cyanotoxins/microcystins from co-cultivated algae (Anabaena, Microcystis, Nodularia), and heavy metals (mercury, lead, cadmium, arsenic) are documented real risks in low-quality products. [42][43]
🚫

Contraindications & Drug Interactions

  • Haemochromatosis: Contraindicated. Very high iron content (81 mg/100 g) could exacerbate iron overload.
  • Phenylketonuria (PKU): Contraindicated. High phenylalanine content (2.8 g/100 g) is dangerous in PKU.
  • Hepatic insufficiency: Avoid. Accumulation of CYP-inhibitory compounds and metabolic load may be problematic.
  • Anticoagulants: Clinically significant interaction. Spirulina slows blood coagulation — additive risk with warfarin, heparin, and other anticoagulants.
  • Immunosuppressants & corticosteroids: Moderate theoretical interaction. Spirulina's immune-activating properties may theoretically antagonise immunosuppression.
  • CYP1A2, CYP2E1, CYP2C6 substrates: Weak CYP inhibition may increase plasma levels of drugs metabolised by these pathways. [41]
  • Pregnancy: No contraindication at moderate doses based on current evidence, provided the product is certified free of contamination.
Clinical Disclaimer: This monograph is for educational and professional reference only. It does not constitute medical advice, diagnosis, or treatment guidance. Arthrospira platensis preparations should be used under the supervision of a qualified healthcare provider. Product quality verification is essential before use. The Health Reference reviews content against current primary literature.
Common Questions

Frequently Asked Questions

Is Spirulina a reliable source of vitamin B12?
No. Despite containing B12-like compounds, the B12 in Spirulina is predominantly pseudovitamin B12 — an inactive corrinoid that does not function as a bioavailable vitamin B12 source in humans. It should not be relied upon by vegetarians or vegans as a B12 supplement. Chlorella is a better-validated algal source of bioavailable B12. Spirulina does, however, legitimately support energy and reduce fatigue through its exceptional vitamin B-complex, iron, and protein content.
Can Spirulina help with allergic rhinitis?
Yes. A randomised clinical trial found Spirulina significantly more effective than placebo for allergic rhinitis. A second clinical study found it comparable to or more effective than cetirizine (a standard antihistamine). The mechanism involves suppression of Th2 cell differentiation via inhibition of IL-4 production, shifting the immune response away from the allergic phenotype.
What is phycocyanin and why is it important?
Phycocyanin is Spirulina's signature bioactive — a blue phycobiliprotein and water-soluble pigment produced during photosynthesis. C-phycocyanin is simultaneously a potent antioxidant (scavenging ROS), anti-inflammatory agent (COX-2 inhibition), and neuroprotectant (protecting neurons against iron-induced toxicity). It is responsible for Spirulina's characteristic blue-green colour and is the most extensively studied of its constituents.
Is Spirulina safe during pregnancy?
There is no contraindication at moderate doses based on current evidence. However, product quality is critical — contamination with pathogenic bacteria, cyanotoxins, or heavy metals poses a real risk with low-quality products. Only certified, third-party tested Spirulina from verified clean cultivation sources should be used. Avoid in hepatic insufficiency and with anticoagulant medications regardless of pregnancy status.
Does Spirulina help with exercise performance and recovery?
Clinical evidence supports this. One study found Spirulina supplementation improves oxygen uptake during arm cycling exercise. A second found it prevents skeletal muscle oxidative damage during intense exercise, improves antioxidant enzyme activity, reduces exercise-induced oxidative stress, and improves fat utilisation. These effects are attributed to phycocyanin's antioxidant capacity and Spirulina's complete amino acid and micronutrient profile.
Can Spirulina interact with medications?
Yes. Spirulina weakly inhibits CYP2E1, CYP1A2, and CYP2C6 — creating a pharmacokinetic interaction risk with drugs metabolised by these enzymes. It slows blood coagulation — a clinically meaningful interaction with anticoagulants such as warfarin. There is a moderate theoretical interaction with immunosuppressants and corticosteroids due to immune activation. It is also contraindicated in haemochromatosis and phenylketonuria.
Primary Literature

Bibliography

↑ 1. Bucaille P. Intérêt et efficacité de l'algue Spiruline dans l'alimentation des enfants présentant une malnutrition protéino-énergétique en milieu tropical: à propos de 28 observations. Thèse de doctorat en Médecine, Université Paul Sabatier, Toulouse III (1990).
↑ 2. Watanabe F, Takenaka S, Kittaka-Katsura H, Ebara S, Miyamoto E. Characterization and bioavailability of vitamin B12-compounds from edible algae. J Nutr Sci Vitaminol (Tokyo). 2002;48(5):325–31. PubMed PMID:12656203 →
↑ 3. Watanabe F. Vitamin B12 sources and bioavailability. Exp Biol Med (Maywood). 2007;232(10):1266–74. PubMed PMID:17959839 →
↑ 4. Kittaka-Katsura H, Fujita T, Watanabe F, Nakano Y. Purification and characterization of a corrinoid compound from Chlorella tablets as an algal health food. J Agric Food Chem. 2002;50(17):4994–7. PubMed PMID:12166996 →
↑ 5. Charpy L, Langlade MJ, Alliod R. La Spiruline peut-elle être un atout pour la santé et le développement en Afrique ? Institut de Recherche pour le Développement. IRD UR 167. Août 2008. Full Text →
↑ 6. Branger B, Cadudal JL, Delobel M, et al. La spiruline comme complément alimentaire dans la malnutrition du nourrisson au Burkina-Faso. Archives de Pédiatrie. 2003;10(5):424–431.
↑ 7. Razafiarisoa B, Ramaroson E, Ramampiherika D. Étude de l'efficacité de Spirulina platensis sur la malnutrition protéino-énergétique et la carence en vitamine A chez les enfants malgaches. In: Colloque international «spiruline et développement». p. 73.
↑ 8. Matip MEN, Stéfanini P. Effets de Spirulina platensis par supplémentation sur le profil lipidique de patients infectés par le VIH sans traitement antirétroviral à Yaoundé.
↑ 9. Zeinalian R, Abbasalizad Farhangi M, Shariat A, Saghafi-Asl M. The effects of Spirulina Platensis on anthropometric indices, appetite, lipid profile and serum vascular endothelial growth factor (VEGF) in obese individuals: a randomized double blinded placebo controlled trial. BMC Complement Altern Med. 2017;17:225. Full Text →
↑ 10. Jung F, Krüger-Genge A, Waldeck P, Küpper JH. Spirulina platensis, a super food? J Cell Biotechnol. 2019;5(1):43–54.
↑ 11. Sahil, Siramdas, Bodh, Suman, Verma P. Spirulina Platensis: A Comprehensive Review of Its Nutritional Value, Antioxidant Activity and Functional Food Potential. 2024:159–172.
↑ 12. Kumar A, Ramamoorthy D, Verma DK, et al. Antioxidant and phytonutrient activities of Spirulina platensis. Energy Nexus. 2022;6:100070. DOI →
↑ 13. Balachandran P, Pugh ND, Ma G, Pasco DS. Toll-like receptor 2-dependent activation of monocytes by Spirulina polysaccharide and its immune enhancing action in mice. Int Immunopharmacol. 2006;6(12):1808–14. PubMed PMID:17052671 →
↑ 14. Pugh N, Ross SA, ElSohly HN, ElSohly MA, Pasco DS. Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa. Planta Med. 2001;67(8):737–42. PubMed PMID:11731916 →
↑ 15. Grzanna R, Polotsky A, Phan PV, Pugh N, Pasco D, Frondoza CG. Immolina, a high-molecular-weight polysaccharide fraction of Spirulina, enhances chemokine expression in human monocytic THP-1 cells. J Altern Complement Med. 2006;12(5):429–35. PubMed PMID:16813506 →
↑ 16. Hayashi O, Ono S, Ishii K, Shi Y, Hirahashi T, Katoh T. Enhancement of proliferation and differentiation in bone marrow hematopoietic cells by Spirulina (Arthrospira) platensis in mice. J Appl Phycol. 2006;18:47–56. DOI →
↑ 17. Cingi C, Conk-Dalay M, Cakli H, Bal C. The effects of spirulina on allergic rhinitis. Eur Arch Otorhinolaryngol. 2008;265(10):1219–23. PubMed PMID:18343939 →
↑ 18. Nourollahian M, Rasoulian B, Gafari A, Anoushiravani M, Jabari F, Bakhshaee M. Clinical comparison of the efficacy of spirulina platensis and cetirizine for treatment of allergic rhinitis. Acta Otorhinolaryngol Ital. 2020;40(3):224–229. PubMed PMID:32773785 →
↑ 19. Lu HK, Hsieh CC, Hsu JJ, Yang YK, Chou HN. Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress. Eur J Appl Physiol. 2006;98(2):220–6. PubMed PMID:16944194 →
↑ 20. Gurney T, Spendiff O. Spirulina supplementation improves oxygen uptake in arm cycling exercise. Eur J Appl Physiol. 2020;120:2341–2348. DOI →
↑ 21. Chu W, Lim Y, Radhakrishnan A, Lim P. Protective effect of aqueous extract from Spirulina platensis against cell death induced by free radicals. BMC Complement Altern Med. 2010;10:53. Full Text →
↑ 22. Piñero Estrada JE, Bermejo Bescós P, Villar del Fresno AM. Antioxidant activity of different fractions of Spirulina platensis protean extract. Farmaco. 2001;56(5–7):497–500. PubMed PMID:11482785 →
↑ 23. Zhang H, Chen T, Jiang J, et al. Selenium-containing allophycocyanin purified from selenium-enriched Spirulina platensis attenuates AAPH-induced oxidative stress in human erythrocytes. J Agric Food Chem. 2011;59(16):8683–90. PubMed PMID:21761878 →
↑ 24. Romay C, Armesto J, Remirez D, González R, Ledon N, García I. Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae. Inflamm Res. 1998;47(1):36–41. PubMed PMID:9495584 →
↑ 25. Romay Ch, González R, Ledón N, Remirez D, Rimbau V. C-phycocyanin: a biliprotein with antioxidant, anti-inflammatory and neuroprotective effects. Curr Protein Pept Sci. 2003;4(3):207–16. PubMed PMID:12769719 →
↑ 26. Romay C, Ledón N, González R. Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation. Inflamm Res. 1998;47(8):334–8. PubMed PMID:9754867 →
↑ 27. Bermejo-Bescós P, Piñero-Estrada E, Villar del Fresno AM. Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells. Toxicol In Vitro. 2008;22(6):1496–502. PubMed PMID:18572379 →
↑ 28. Trotta T, Porro C, Cianciulli A, Panaro MA. Beneficial Effects of Spirulina Consumption on Brain Health. Nutrients. 2022;14(3):676. PubMed PMID:35277035 →
↑ 29. Wang Y, Chang CF, Chou J, et al. Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage. Exp Neurol. 2005;193(1):75–84. PubMed PMID:15817266 →
↑ 30. Pabon MM, Jernberg JN, Morganti J, et al. A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease. PLoS One. 2012;7(9):e45256. PubMed PMID:23028885 →
↑ 31. Zhang F, Lu J, Zhang JG, Xie JX. Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPTP-induced Parkinson's disease model in C57BL/6J mice. Neural Regen Res. 2015;10(2):308–13. PubMed PMID:25883632 →
↑ 32. Pabon MM, Jernberg JN, Morganti J, et al. A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease. PLoS One. 2012;7(9):e45256. PubMed PMID:23028885 →
↑ 33. Bachstetter AD, Jernberg J, Schlunk A, et al. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation. PLoS One. 2010;5(5):e10496. PMC Full Text →
↑ 34. Bickford PC, Tan J, Shytle RD, Sanberg CD, El-Badri N, Sanberg PR. Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev. 2006;15(1):118–23. PubMed PMID:16522169 →
↑ 35. El-Desoky GE, Bashandy SA, Alhazza IM, et al. Improvement of mercuric chloride-induced testis injuries and sperm quality deteriorations by Spirulina platensis in rats. PLoS One. 2013;8(3):e59177. PubMed PMID:23555627 →
↑ 36. Farooq SM, Asokan D, Kalaiselvi P, Sakthivel R, Varalakshmi P. Prophylactic role of phycocyanin: a study of oxalate mediated renal cell injury. Chem Biol Interact. 2004;149(1):1–7. PubMed PMID:15294440 →
↑ 37. Girardin-Andréani C. Spiruline: système sanguin, système immunitaire et cancer. Phytotherapie. 2005;3:158. DOI →
↑ 38. Mao TK, Van de Water J, Gershwin ME. Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients. J Med Food. 2005;8(1):27–30. PubMed PMID:15857205 →
↑ 39. Arthur-Ataam J, Bideaux P, Charrabi A, et al. Dietary Supplementation with Silicon-Enriched Spirulina Improves Arterial Remodeling and Function in Hypertensive Rats. Nutrients. 2019;11(11):2574. PubMed PMID:31731463 →
↑ 40. Pétrus M, Assih L, Horea B, et al. Premier cas d'allergie à la spiruline chez un enfant de treize ans. Revue Française d'Allergologie. 2010;50(5):470–472.
↑ 41. Savranoglu S, Tumer TB. Inhibitory effects of spirulina platensis on carcinogen-activating cytochrome P450 isozymes and potential for drug interactions. Int J Toxicol. 2013;32(5):376–84. PubMed PMID:24082030 →
↑ 42. Manet A. La spiruline: indications thérapeutiques, risques sanitaires et conseils à l'officine. Sciences pharmaceutiques. 2016. dumas-01346709. Full Text →
↑ 43. ANSES. Avis de l'Anses relatif aux risques relatifs à la consommation de compléments alimentaires contenant de la spiruline. Saisine n° 2014-SA-0096. 04/08/2017. ANSES Full Report →